ביולוגיה של התא למתקדמים: תגובות תאיות לעקה בבריאות ובמחלות (0440.3125)
שם הקורס באנגלית: Advanced cell biology: Cellular Responses to Stress in Health and Disease
ימים ושעות הקורס
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Perturbations to cellular homeostasis require integrative responses, involving multiple molecular mechanisms, for its restoration. Success or lack of success in this endeavor can be a central determinant between health and disease. Indeed, cellular responses to stress span the entire spectrum of cellular activities, from maintenance/alteration of chromosomal copy numbers to synthesis/turnover of all types of biological macromolecules (e.g. proteins). As such, the mechanisms involved in stress induction and/or its resolution are the subject of intense study and serve as targets for novel therapeutics. In this course, we will study the molecular mechanisms involved in such responses with emphasis on different sources of cellular stress, including toxic drugs, oxidative stress, genetic diseases, protein misfolding and viral infection. In addition, we will expand on the experimental techniques involved in the study of cellular stress, and the model systems in which these phenomena are currently studied.
The course is based on mandatory participation in weekly meetings during the semester. Each week will include a frontal lecture and active discussion based on prior obligatory reading of related papers.
Prior courses requirement:
Cell biology, Molecular biology and biotechnology, Genetics.
Attendance in class is obligatory. No more than 3 missing classes are allowed.
70% final home exam;
30% active participation in class discussions + final summary discussion