פרופ' יפתח נחמן
סגל אקדמי בכיר בבית הספר לנוירובילוגיה ביוכימיה וביופיזיקה
מנהלת הפקולטה למדעי החיים
בית הספר לנוירובילוגיה ביוכימיה וביופיזיקה
סגל אקדמי בכיר
The Nachman Lab focuses on understanding early developmental cell fate decisions and patterning at the phenotypic and mechanistic level. We use embryonic stem cell-based in-vitro models (including Gastruloids and Trunk-Like Structures), combining live cell imaging (e.g., two-photon microscopy), and advanced computational/statistical methods to investigate how signaling networks and intrinsic cellular properties govern robust developmental timing and fate choice.
Some recent and ongoing projects:
- Initial symmetry breaking and mesendoderm differentiation
- Onset and patterning of definitive endoderm
- Effects of signal perturbations on advanced gut development
- Effects of common teratogens (e.g. nicotine, caffeine) on early cardiac development
- Embryo models in common livestock species (sheep, pig)
Selected Key Publications
A full list of publications is available on the Lab Website.
- Farag N, Sacharen C, Avni L, Nachman I. (2024). Coordination between endoderm progression and mouse gastruloid elongation controls endodermal morphotype choice. Developmental Cell. S1534-5807(24)00335-6.
- Hauser M, Zirman A, Rak R, Nachman I. (2024). Challenges and opportunities in cell expansion for cultivated meat. Frontiers in Nutrition. 11:1315555.
- Pour M, Kumar AS, Farag N, et al., Nachman I. (2022). Emergence and patterning dynamics of mouse definitive endoderm. iScience. 25(1): 103556.
- JV Veenvliet, PF Lenne, DA Turner, I Nachman, V Trivedi. (2021). Sculpting with stem cells: how models of embryo development take shape. Development. 148(24): dev192914.
- Sagy N, Slovin S, Allalouf M, Pour M, Savyon G, Boxman J, Nachman I. (2019). Prediction and control of symmetry breaking in embryoid bodies by environment and signal integration. Development. 146 (20): dev181917.
- Boxman J, Sagy N, Achanta S, Vadigepalli R, Nachman I. (2016). Integrated live imaging and molecular profiling of embryoid bodies reveals a synchronized progression of early differentiation. Scientific Reports. 6:31623.
- Pour M†, Pilzer I†, Rosner R, Smith ZD, Meissner A, Nachman I. (2015). Epigenetic predisposition to reprogramming fates in somatic cells. EMBO Reports. 16(3): 370-378.
- Smith ZD*, Nachman I*, Regev A, Meissner A. (2010). Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nature Biotechnology. 28(5): 521-6.
- Nachman I, Regev A, Ramanathan S. (2007). Dissecting timing variability in yeast meiosis. Cell. 131(3): 544–556.
