הנדסת נוגדנים (0453.3388)
עודכן: 08.07.2018
שם הקורס באנגלית: Antibody Engineering
| סוג: שיעור | ||||||
| מספר קורס | סמסטר | יום | משעה | עד שעה | בניין | חדר |
| 0453.3388.01 | א | ה | 10:00 | 12:00 | שרמן | 003 |
סילבוס:
Antibody engineering profession, the key discoveries that shaped it to what it is today. Many of the principles we cover are relevant to biotechnology and in particular, to drug-discovery and development in general.
During the 13 lectures, 2 hours each, the following topics will be discussed.
1) Introduction to Antibody Engineering. The entire field at a glance.
2) The generation of diversity and the tools for studying antibody repertoires.
3) Antibody structure, the immunoglobulin fold and the structure-function correlates of antibodies.
4) Bioinformatic tools and databases for studying antibodies.
5) Cloning antibody genes and expression of antibodies in bacteria.
6) Antibody humanization and de-immunization.
7) Stabilization of antibodies.
8) Isolating human antibodies from transgenic animals.
9) Antibody discovery by display technologies.
10) Armed antibodies; antibody-drug conjugates, immunotoxins, radio-immuno-conjugates.
During the 13 lectures, 2 hours each, the following topics will be discussed.
1) Introduction to Antibody Engineering. The entire field at a glance.
2) The generation of diversity and the tools for studying antibody repertoires.
3) Antibody structure, the immunoglobulin fold and the structure-function correlates of antibodies.
4) Bioinformatic tools and databases for studying antibodies.
5) Cloning antibody genes and expression of antibodies in bacteria.
6) Antibody humanization and de-immunization.
7) Stabilization of antibodies.
8) Isolating human antibodies from transgenic animals.
9) Antibody discovery by display technologies.
10) Armed antibodies; antibody-drug conjugates, immunotoxins, radio-immuno-conjugates.
דרישות קדם: אימונולוגיה כללית
נוכחות חובה
הרכב ציון:
The final grade is based on a multiple-choice exam (3 hours) containing 40 questions. Written materials are allowed in the exam but not any electronic devices.
מטלת סיום: בחינה בכתב
